At the Open Source Lab we host many of our sites as a Drupal multisite. This means that we have several instances of Drupal using the same theme, and then we can populate each site with different content as needed (for instance, cass.oregonstate.edu and osuosl.org would be different websites with different messages, but with Drupal they can look and act the same. Pretty neat!). Since not all of our sites are used by the OSL (i.e. the Center for Applied Systems and Software), I recently needed to make our logo and organization name into variables so that the user could just upload an image and fill in a text box to customize the site theme to their organization. Luckily, Drupal makes my job pretty easy.